A draft map of cis-regulatory sequences in the mouse genome [HiC]
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ABSTRACT: As the most widely used mammalian model organism, mice play a critical role in biomedical research for mechanistic study of human development and diseases. Today, functional sequences in the mouse genome are still poorly annotated a decade after its initial sequencing. We report here a map of nearly 300,000 cis-regulatory sequences in the mouse genome, representing active promoters, enhancers and CTCF binding sites in a diverse set of 19 tissues and cell types. This map provides functional annotation to nearly 11% of the genome, and over 70% of conserved, non-coding sequences. We define tissue-specific enhancers and identify potential transcription factors regulating gene expression in each tissue or cell type. Finally, we demonstrate that cis-regulatory sequences are organized into domains of coordinately regulated enhancers and promoters. Our results provide a valuable resource for the annotation of functional elements in the mammalian genome, and study of regulatory mechanisms for tissue-specific gene expression. Cortex Hi-C experiment were conducted in biological replicates
ORGANISM(S): Mus musculus
SUBMITTER: Bing Ren
PROVIDER: E-GEOD-34587 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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