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Transcription profiling of gonadal somatic cells from gonads of male and female transgenic pSF1-eGFP mice

ABSTRACT: Gene expression profiling of FACS sorted GFP+ve cells from sexed gonads of transgenic pSF1-eGFP mice

ORGANISM(S): Mus musculus

SUBMITTER: Sean Grimmond

PROVIDER: E-GEOD-3463 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes.

Beverdam Annemiek A Koopman Peter P

Human molecular genetics 20060106 3

Despite the identification of SRY as the testis-determining gene in mammals, the genetic interactions controlling the earliest steps of male sex determination remain poorly understood. In particular, the molecular lesions underlying a high proportion of human XY gonadal dysgenesis, XX maleness and XX true hermaphroditism remain undiscovered. A number of screens have identified candidate genes whose expression is modulated during testis or ovary differentiation in mice, but these screens have use ...[more]

PMID: 16399799

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