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Expression data from primary central nervous system lymphoma (PCNSL) patients

ABSTRACT: This study aimed to define the genes associated with PCNSL patient survival. Expression profiling was performed on 34 PCNSLs. A gene classifier was developed. Thirty-four PCNSL patients were selected for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: ryuya yamanaka 

PROVIDER: E-GEOD-34771 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression signature-based prognostic risk score in patients with primary central nervous system lymphoma.

Kawaguchi Atsushi A   Iwadate Yasuo Y   Komohara Yoshihiro Y   Sano Masakazu M   Kajiwara Koji K   Yajima Naoki N   Tsuchiya Naoto N   Homma Jumpei J   Aoki Hiroshi H   Kobayashi Tsutomu T   Sakai Yuko Y   Hondoh Hiroaki H   Fujii Yukihiko Y   Kakuma Tatsuyuki T   Yamanaka Ryuya R  

Clinical cancer research : an official journal of the American Association for Cancer Research 20120820 20

<h4>Purpose</h4>Better understanding of the underlying biology of primary central nervous system lymphomas (PCNSL) is critical for the development of early detection strategies, molecular markers, and new therapeutics. This study aimed to define genes associated with survival of patients with PCNSL.<h4>Experimental design</h4>Expression profiling was conducted on 32 PCNSLs. A gene classifier was developed using the random survival forests model. On the basis of this, prognosis prediction score (  ...[more]

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