Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Epigenetic reprogramming in relapsed childhood ALL


ABSTRACT: Reversing gene expression signatures in relapsed patient may restore chemosensitivity. We demonstrate that the histone deacetylase inhibitor vorinostat not only reprograms the aberrant gene expression profile of relapsed blasts but is synergistic when applied prior to chemotherapy in primary patient samples and leukemia cell lines Primary patient samples were collected from patients treated at the New York University Medical Center and from the Children’s Oncology Group (COG) cell bank,RNA was isolated from three primary patient samples and three B-lineage leukemia cell lines with or without treatment with vorinostat for 24 hours.

ORGANISM(S): Homo sapiens

SUBMITTER: Teena Bhatla 

PROVIDER: E-GEOD-34880 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia.

Bhatla Teena T   Wang Jinhua J   Morrison Debra J DJ   Raetz Elizabeth A EA   Burke Michael J MJ   Brown Patrick P   Carroll William L WL  

Blood 20120411 22


Whereas the improvement in outcome for children with acute lymphoblastic leukemia has been gratifying, the poor outcome of patients who relapse warrants novel treatment approaches. Previously, we identified a characteristic relapse-specific gene expression and methylation signature associated with chemoresistance using a large cohort of matched-diagnosis relapse samples. We hypothesized that "reversing" such a signature might restore chemosensitivity. In the present study, we demonstrate that th  ...[more]

Similar Datasets

2012-06-12 | GSE34880 | GEO
2013-12-21 | E-GEOD-43060 | biostudies-arrayexpress
2008-06-15 | E-GEOD-7210 | biostudies-arrayexpress
2017-02-09 | E-MTAB-4715 | biostudies-arrayexpress
2009-02-07 | E-GEOD-14618 | biostudies-arrayexpress
2022-03-23 | GSE190942 | GEO
2011-09-22 | E-GEOD-28462 | biostudies-arrayexpress
2008-04-04 | E-TABM-255 | biostudies-arrayexpress
2015-05-07 | E-GEOD-52891 | biostudies-arrayexpress
2024-02-15 | GSE237794 | GEO