Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Natalia Ivanova
PROVIDER: E-GEOD-34921 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Zheng Z Oron Efrat E Nelson Brynna B Razis Spiro S Ivanova Natalia N
Cell stem cell 20120401 4
Nanog, Oct4, and Sox2 are the core regulators of mouse (m)ESC pluripotency. Although their basic importance in human (h)ESCs has been demonstrated, the mechanistic functions are not well defined. Here, we identify general and cell-line-specific requirements for NANOG, OCT4, and SOX2 in hESCs. We show that OCT4 regulates, and interacts with, the BMP4 pathway to specify four developmental fates. High levels of OCT4 enable self-renewal in the absence of BMP4 but specify mesendoderm in the presence ...[more]