Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE34904: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 1) GSE34912: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 2) GSE34918: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 3) GSE34920: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 4) Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Natalia Ivanova 

PROVIDER: E-GEOD-34921 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells.

Wang Zheng Z   Oron Efrat E   Nelson Brynna B   Razis Spiro S   Ivanova Natalia N  

Cell stem cell 20120401 4


Nanog, Oct4, and Sox2 are the core regulators of mouse (m)ESC pluripotency. Although their basic importance in human (h)ESCs has been demonstrated, the mechanistic functions are not well defined. Here, we identify general and cell-line-specific requirements for NANOG, OCT4, and SOX2 in hESCs. We show that OCT4 regulates, and interacts with, the BMP4 pathway to specify four developmental fates. High levels of OCT4 enable self-renewal in the absence of BMP4 but specify mesendoderm in the presence  ...[more]

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