Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Lance David Miller
PROVIDER: E-GEOD-3494 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Miller Lance D LD Smeds Johanna J George Joshy J Vega Vinsensius B VB Vergara Liza L Ploner Alexander A Pawitan Yudi Y Hall Per P Klaar Sigrid S Liu Edison T ET Bergh Jonas J
Proceedings of the National Academy of Sciences of the United States of America 20050902 38
Perturbations of the p53 pathway are associated with more aggressive and therapeutically refractory tumors. However, molecular assessment of p53 status, by using sequence analysis and immunohistochemistry, are incomplete assessors of p53 functional effects. We posited that the transcriptional fingerprint is a more definitive downstream indicator of p53 function. Herein, we analyzed transcript profiles of 251 p53-sequenced primary breast tumors and identified a clinically embedded 32-gene express ...[more]