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Transcription profiling of human breast cancer patients sensitive to docetaxel

ABSTRACT: These patients were sensitive to docetaxel treatment, exhibiting less than 25% residual tumor.

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Wooten

PROVIDER: E-GEOD-350 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer.

Chang Jenny C JC Wooten Eric C EC Tsimelzon Anna A Hilsenbeck Susan G SG Gutierrez M Carolina MC Elledge Richard R Mohsin Syed S Osborne C Kent CK Chamness Gary C GC Allred D Craig DC O'Connell Peter P

Lancet (London, England) 20030801 9381

<h4>Background</h4>Systemic chemotherapy for operable breast cancer substantially decreases the risk of death. Patients often have de novo resistance or incomplete response to docetaxel, one of the most active agents in this disease. We postulated that gene expression profiles of the primary breast cancer can predict the response to docetaxel.<h4>Methods</h4>We took core biopsy samples from primary breast tumours in 24 patients before treatment and then assessed tumour response to neoadjuvant do ...[more]

PMID: 12907009

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