Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Tim Roloff
PROVIDER: E-GEOD-35118 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Aceto Nicola N Sausgruber Nina N Brinkhaus Heike H Gaidatzis Dimos D Martiny-Baron Georg G Mazzarol Giovanni G Confalonieri Stefano S Quarto Micaela M Hu Guang G Hu Guang G Balwierz Piotr J PJ Pachkov Mikhail M Elledge Stephen J SJ van Nimwegen Erik E Stadler Michael B MB Bentires-Alj Mohamed M
Nature medicine 20120304 4
New cancer therapies are likely to arise from an in-depth understanding of the signaling networks influencing tumor initiation, progression and metastasis. We show a fundamental role for Src-homology 2 domain-containing phosphatase 2 (SHP2) in these processes in human epidermal growth factor receptor 2 (HER2)-positive and triple-negative breast cancers. Knockdown of SHP2 eradicated breast tumor-initiating cells in xenograft models, and SHP2 depletion also prevented invasion in three-dimensional ...[more]