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Genome-wide occupancy profile of Tbx3, Gata4, Nkx2-5 and p300 in adult mouse whole heart

ABSTRACT: The contraction pattern of the heart relies on the activation and conduction of the electrical impulse. Perturbations of cardiac conduction have been associated with congenital and acquired arrhythmias as well as cardiac arrest. The pattern of conduction depends on the regulation of heterogeneous gene expression by key transcription factors and transcriptional enhancers. Here, we assessed the genome-wide occupation of conduction system–regulating transcription factors TBX3, NKX2-5, and GATA4 and of enhancer-associated coactivator p300 in the mouse heart, uncovering cardiac enhancers throughout the genome. Examination of 3 cardiac transcription factors and p300 in adult mouse heart

ORGANISM(S): Mus musculus

SUBMITTER: Vincent Christoffels

PROVIDER: E-GEOD-35151 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.

van den Boogaard Malou M Wong L Y Elaine LY Tessadori Federico F Bakker Martijn L ML Dreizehnter Lisa K LK Wakker Vincent V Bezzina Connie R CR 't Hoen Peter A C PA Bakkers Jeroen J Barnett Phil P Christoffels Vincent M VM

The Journal of clinical investigation 20120618 7

The contraction pattern of the heart relies on the activation and conduction of the electrical impulse. Perturbations of cardiac conduction have been associated with congenital and acquired arrhythmias as well as cardiac arrest. The pattern of conduction depends on the regulation of heterogeneous gene expression by key transcription factors and transcriptional enhancers. Here, we assessed the genome-wide occupation of conduction system-regulating transcription factors TBX3, NKX2-5, and GATA4 and ...[more]

PMID: 22706305

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