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Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE35201: Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases [2007] GSE35202: Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases [2010] Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Tanja Gruber 

PROVIDER: E-GEOD-35203 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.

Gruber Tanja A TA   Larson Gedman Amanda A   Zhang Jinghui J   Koss Cary S CS   Marada Suresh S   Ta Huy Q HQ   Chen Shann-Ching SC   Su Xiaoping X   Ogden Stacey K SK   Dang Jinjun J   Wu Gang G   Gupta Vedant V   Andersson Anna K AK   Pounds Stanley S   Shi Lei L   Easton John J   Barbato Michael I MI   Mulder Heather L HL   Manne Jayanthi J   Wang Jianmin J   Rusch Michael M   Ranade Swati S   Ganti Ramapriya R   Parker Matthew M   Ma Jing J   Radtke Ina I   Ding Li L   Cazzaniga Giovanni G   Biondi Andrea A   Kornblau Steven M SM   Ravandi Farhad F   Kantarjian Hagop H   Nimer Stephen D SD   Döhner Konstanze K   Döhner Hartmut H   Ley Timothy J TJ   Ballerini Paola P   Shurtleff Sheila S   Tomizawa Daisuke D   Adachi Souichi S   Hayashi Yasuhide Y   Tawa Akio A   Shih Lee-Yung LY   Liang Der-Cherng DC   Rubnitz Jeffrey E JE   Pui Ching-Hon CH   Mardis Elaine R ER   Wilson Richard K RK   Downing James R JR  

Cancer cell 20121101 5


To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated our findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples. Our analysis identified a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric cases, which encodes a CBFA2T3-GLIS2 fusion protein. Expression of CBFA2T3-GLIS2 in Drosophila and  ...[more]

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