Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Array-based DNA-methylation profiling of fetal tissues obtained by routine invasive prenatal testing (chorionic and amniotic samples)

ABSTRACT: Genome wide DNA methylation profiling of fetal DNA-methylation levels in 47 chorionic villi (CVS) and 16 amniotic cell (AC) samples. The Illumina Infinium 27k Human DNA methylation Beadchip was used to determine DNA methylation profiles across approximately 27,578 CpGs in fetal samples. Bisulphite converted DNA from the 61 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip (2 sample in duplicate pairs)

ORGANISM(S): Homo sapiens

SUBMITTER: Ole Ammerpohl

PROVIDER: E-GEOD-35327 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

DNA-methylation profiling of fetal tissues reveals marked epigenetic differences between chorionic and amniotic samples.

Eckmann-Scholz Christel C Bens Susanne S Kolarova Julia J Schneppenheim Sina S Caliebe Almuth A Heidemann Simone S von Kaisenberg Constantin C Kautza Monika M Jonat Walter W Siebert Reiner R Ammerpohl Ole O

PloS one 20120619 6

Epigenetic mechanisms including DNA methylation are supposed to play a key role in fetal development. Here we have investigated fetal DNA-methylation levels of 27,578 CpG loci in 47 chorionic villi (CVS) and 16 amniotic cell (AC) samples. Methylation levels differed significantly between karyotypically normal AC and CVS for 2,014 genes. AC showed more extreme DNA-methylation levels of these genes than CVS and the differentially methylated genes are significantly enriched for processes characteri ...[more]

PMID: 22723920

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Dataset Information

Array-based DNA-methylation profiling of fetal tissues obtained by routine invasive prenatal testing (chorionic and amniotic samples)

Publications

DNA-methylation profiling of fetal tissues reveals marked epigenetic differences between chorionic and amniotic samples.

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