Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Emily Bernstein
PROVIDER: E-GEOD-35339 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ratnakumar Kajan K Duarte Luis F LF LeRoy Gary G Hasson Dan D Smeets Daniel D Vardabasso Chiara C Bönisch Clemens C Zeng Tianying T Xiang Bin B Zhang David Y DY Li Haitao H Wang Xiaowo X Hake Sandra B SB Schermelleh Lothar L Garcia Benjamin A BA Bernstein Emily E
Genes & development 20120301 5
The histone variant macroH2A generally associates with transcriptionally inert chromatin; however, the factors that regulate its chromatin incorporation remain elusive. Here, we identify the SWI/SNF helicase ATRX (α-thalassemia/MR, X-linked) as a novel macroH2A-interacting protein. Unlike its role in assisting H3.3 chromatin deposition, ATRX acts as a negative regulator of macroH2A's chromatin association. In human erythroleukemic cells deficient for ATRX, macroH2A accumulates at the HBA gene cl ...[more]