Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Anna Bigas
PROVIDER: E-GEOD-35395 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of experimental medicine 20120716 8
Understanding how hematopoietic stem cells (HSCs) are generated and the signals that control this process is a crucial issue for regenerative medicine applications that require in vitro production of HSC. HSCs emerge during embryonic life from an endothelial-like cell population that resides in the aorta-gonad-mesonephros (AGM) region. We show here that β-catenin is nuclear and active in few endothelial nonhematopoietic cells closely associated with the emerging hematopoietic clusters of the emb ...[more]