Unknown,Transcriptomics,Genomics,Proteomics

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Mediator promotes CENP-A incorporation at fission yeast centromeres


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE32310: Transcriptome analysis of mediator Med20 mutant and dcr1 mutant in S.pombe GSE35524: Mediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq] Refer to individual Series

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Claes Gustafsson 

PROVIDER: E-GEOD-35527 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mediator promotes CENP-a incorporation at fission yeast centromeres.

Carlsten Jonas O JO   Szilagyi Zsolt Z   Liu Beidong B   Lopez Marcela Davila MD   Szászi Erzsébet E   Djupedal Ingela I   Nyström Thomas T   Ekwall Karl K   Gustafsson Claes M CM   Zhu Xuefeng X  

Molecular and cellular biology 20120730 19


At Schizosaccharomyces pombe centromeres, heterochromatin formation is required for de novo incorporation of the histone H3 variant CENP-A(Cnp1), which in turn directs kinetochore assembly and ultimately chromosome segregation during mitosis. Noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (Pol II) directs heterochromatin formation through not only the RNA interference (RNAi) machinery but also RNAi-independent RNA processing factors. Control of centromeric ncRNA transcription is theref  ...[more]

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