Ontology highlight
ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Claes Gustafsson
PROVIDER: E-GEOD-35527 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Carlsten Jonas O JO Szilagyi Zsolt Z Liu Beidong B Lopez Marcela Davila MD Szászi Erzsébet E Djupedal Ingela I Nyström Thomas T Ekwall Karl K Gustafsson Claes M CM Zhu Xuefeng X
Molecular and cellular biology 20120730 19
At Schizosaccharomyces pombe centromeres, heterochromatin formation is required for de novo incorporation of the histone H3 variant CENP-A(Cnp1), which in turn directs kinetochore assembly and ultimately chromosome segregation during mitosis. Noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (Pol II) directs heterochromatin formation through not only the RNA interference (RNAi) machinery but also RNAi-independent RNA processing factors. Control of centromeric ncRNA transcription is theref ...[more]