Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Rob Mariman
PROVIDER: E-GEOD-35609 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kremer Bas B Mariman Rob R van Erk Marjan M Lagerweij Tonny T Nagelkerken Lex L
PloS one 20121130 11
The recurrent TNBS-colitis model in BALB/c mice has been proposed as a model of Inflammatory Bowel Disease with a shifting pattern of local cytokines with the expression of Th1 cytokines during the early phase, Th17 cytokines during the intermediate phase and Th2 cytokines during late fibrotic stages. In this study, we evaluated the development of pathology in time-in conjunction with genome-wide gene expression in the colons-in response to three weekly intrarectal instillations of TNBS. During ...[more]