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MicroRNA discovery and analysis of Dirofilaria immitis by deep sequencing.

ABSTRACT: To understand how microRNA are involved in the complex biology of this zoonotic parasite, we describe our initial attempts to characterize small RNA in adult Dirofilaria immitis by using Illumina/Solexa deep-sequencing technology. Examination of 4 different adult Dirofilaria immitis (pooled)

ORGANISM(S): Dirofilaria immitis

SUBMITTER: Guangyou Yang

PROVIDER: E-GEOD-35646 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of Dirofilaria immitis miRNA using illumina deep sequencing.

Fu Yan Y Lan Jingchao J Wu Xuhang X Yang Deying D Zhang Zhihe Z Nie Huaming H Hou Rong R Zhang Runhui R Zheng Wanpeng W Xie Yue Y Yan Ning N Yang Zhi Z Wang Chengdong C Luo Li L Liu Li L Gu Xiaobin X Wang Shuxian S Peng Xuerong X Yang Guangyou G

Veterinary research 20130118

The heartworm Dirofilaria immitis is the causative agent of cardiopulmonary dirofilariosis in dogs and cats, which also infects a wide range of wild mammals and humans. The complex life cycle of D. immitis with several developmental stages in its invertebrate mosquito vectors and its vertebrate hosts indicates the importance of miRNA in growth and development, and their ability to regulate infection of mammalian hosts. This study identified the miRNA profiles of D. immitis of zoonotic significan ...[more]

PMID: 23331513

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