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Kinetic RNA polymerase II occupancy, associated histone marks, and mRNA accumulation reveal transcriptional and post-transcriptional mechanisms underlying circadian gene expression

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Nouria Hernandez

PROVIDER: E-GEOD-35790 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles.

Le Martelot Gwendal G Canella Donatella D Symul Laura L Migliavacca Eugenia E Gilardi Federica F Liechti Robin R Martin Olivier O Harshman Keith K Delorenzi Mauro M Desvergne Béatrice B Herr Winship W Deplancke Bart B Schibler Ueli U Rougemont Jacques J Guex Nicolas N Hernandez Nouria N Naef Felix F

PLoS biology 20121127 11

Interactions of cell-autonomous circadian oscillators with diurnal cycles govern the temporal compartmentalization of cell physiology in mammals. To understand the transcriptional and epigenetic basis of diurnal rhythms in mouse liver genome-wide, we generated temporal DNA occupancy profiles by RNA polymerase II (Pol II) as well as profiles of the histone modifications H3K4me3 and H3K36me3. We used these data to quantify the relationships of phases and amplitudes between different marks. We foun ...[more]

PMID: 23209382

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Genome-wide profiles of RNA polymerase II (Pol 2) DNA occupancy and the histone modifications H3K4me3 and H3K36me3 around the circadian cycle

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