Unknown,Transcriptomics,Genomics,Proteomics

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Insights into Dahl salt-sensitive hypertension revealed

ABSTRACT: The results of this study identified a number of pathways potentially important for the amelioration of hypertension and renal injury in SS-13BN/Mcw rats, and these results generated a series of testable hypotheses related to the role of the renal medulla in the complex mechanism of salt-sensitive hypertension. Rats were paired for microarray hybridization, and the results were analyzed. Each of the four between-group comparisons comprised three pairs of rats examined by six microarrays with dye switching for each pair. Dye switching was not necessary for within-group comparisons, because the two rats of each pair were equivalent in terms of their treatment status. The expression data from the present study were combined with those from 24 microarrays hybridized in our previous study and used to identify genes exhibiting the most distinct temporal patterns of expression between SS and SS-13BN/Mcw over the time course studied.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Baozhi Yuan

PROVIDER: E-GEOD-3588 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression.

Liang Mingyu M Yuan Baozhi B Rute Elizabeth E Greene Andrew S AS Olivier Michael M Cowley Allen W AW

Physiological genomics 20030206 3

Dahl salt-sensitive SS and consomic, salt-resistant SS-13(BN)/Mcw rats possess a highly similar genetic background but exhibit substantial differences in blood pressure salt sensitivity. We used cDNA microarrays to examine sequential changes of mRNA expression of approximately 2,000 currently known rat genes in the renal medulla (a tissue critical for long-term blood pressure regulation) in SS and SS-13(BN)/Mcw rats in response to a high-salt diet (16 h, 3 days, or 2 wk). Differentially expresse ...[more]

PMID: 12488510

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Insights into Dahl salt-sensitive hypertension revealed

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Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression.

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