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Transcription profiling of rat exposed to isoflurane single exposure - 1 hour or 2 hour

ABSTRACT: 3 controls, 2 1-hr exposure, and 3 2-hr exposure. RNA extractions and microarray hybridization were performed at the University of of California, Davis. Male Sprague Dawley rats were used in this study and were intubated during the exposures.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Roderic Eckenhoff

PROVIDER: E-GEOD-359 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Isoflurane Single Exposures

Project description:3 controls, 2 1-hr exposure, and 3 2-hr exposure. RNA extractions and microarray hybridization were performed at the University of of California, Davis. Male Sprague Dawley rats were used in this study and were intubated during the exposures. Keywords = Eckenhoff Keywords = anesthetics Keywords: time-course

2003-06-26 | GSE359 | GEO

Synergism of Iraqi Sand/Cigarette Smoke Co-Exposure in Rats

Project description:Synergism of Iraqi Sand/Cigarette Smoke Co-Exposure in Rats. 24 samples are used. A total of 102 rats will be separated into six exposure groups: each group consisting of 17 male CD Sprague-Dawley rats, 10 to 15 weeks old. The six exposure groups were each exposed via two routes: 1. nose-only inhalation exposures --- air or cigarette smoke; 2. whole-body inhalation exposures -- air or manufactured silica sand or Iraqi sand. The nose only exposures were conducted 3 hours per day, 5 days per week for 6 weeks. During the last two weeks of the nose - only exposures, whole-body exposure were also conducted 18-19 hours per day, 7 days per week.

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Isoflurane Repetitive Exposure

Project description:12 Controls, 3 5-exposures, 3 10-exposures. Rats were exposed to 90 minutes of 1.0% isoflurane twice a day for a total of 5 or 10 exposures. Animals did not require intubation. All exposures and hybridizations were performed at the Univ. of Pennsylvania. Keywords: time-course

2003-06-26 | GSE358 | GEO

Bis-(2-chloroethyl) sulfide exposure time course and dose response in the rat lung

Project description:Male Sprague-dawley rats were exposed to saline, isopropyl alcohol, 1mg/kg, 3mg/kg or 6 mg/kg sulfur mustard for 30 min, 1 hr, 3 hr, 6 hr, or 24 hr before analysis of lung tissue by oligonucleotide array analysis. Keywords = sulfur mustard Keywords = rat Keywords = lung Keywords = bis-(2-chloroethyl) sulfide Keywords: ordered

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Halothane/Isoflurane repetitive exposures

Project description:Halothane/Isoflurane repetitive exposures

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Effects of single or 35 days oral exposure of adult Sprague-Dawley rats to p-tert-octylphenol on uterine gene expression

Project description:Contamination of the environment with endocrine disrupting chemicals (EDCs) has raised concerns about potential health hazards for humans and wildlife. P-tert-octylphenol (OP) is one such ubiquitous chemical reported to bind to the estrogen receptor (ER) and alter expression of estrogen-responsive genes. Human and wildlife exposure to OP are likely, due to its persistence in the environment and its presence in food, water and items of daily use. Detrimental effects of OP exposures on the reproductive system have been observed in some, but not all, in vivo experiments. This study compared estrogenic effects of OP in vitro with those in vivo in adult female rats, attempting to better mimic real-life exposures in adults. In vitro, OP bound to human ER weakly and accelerated proliferation of MCF-7 cells. Adult Sprague-Dawley rats were given OP by gavage either once or daily for 35 days (125 mg/kg body weight). Body and organ weights and ovarian follicle populations were unaltered in OP-exposed adult rats after either time point, despite detectable levels of OP in reproductive organs. Toxicity of OP was demonstrated by a slightly reduced growth rate and slightly altered estrous cycle, but there were no significant estrogen-like changes in histomorphology or microarray analyses of gene expression of uterine tissue. Prepubertal rats exposed by gavage to 125 or 250 mg/kg OP for three days failed to show any uterotrophic effects, although E2 caused a 3-fold increase in uterine weight. Results do not support a dose-dependent, estrogenic mode of action for OP. This SuperSeries is composed of the following subset Series: GSE14527: Effects of single oral exposure of adult Sprague-Dawley rats to p-tert-octylphenol on uterine gene expression GSE14528: Effects of 35 days oral exposure of adult female Sprague-Dawley rats to p-tert-octylphenol on uterine gene expression Refer to individual Series

2009-02-20 | E-GEOD-14530 | biostudies-arrayexpress

Halothane/Isoflurane Repetitive Exposures

Project description:Rats were exposed to 90 minutes of 0.8% halothane or 1.0% isoflurane twice a day for a total of 5 or 10 exposures. Animals did not require intubation. All exposures and hybridizations were performed at the Univ. of Pennsylvania. Keywords = anesthetics Keywords: other

2003-10-20 | GSE752 | GEO

Transcription profiling of lung tissue of male Sprague Dawley rats after exposure to saline, isopropyl alcohol and sulfur mustard for 30 min, 1 hr, 3 hr, 6 hr, or 24 hr

Project description:Male Sprague-Dawley rats were exposed to saline, isopropyl alcohol, 1mg/kg, 3mg/kg or 6 mg/kg sulfur mustard for 30 min, 1 hr, 3 hr, 6 hr, or 24 hr before analysis of lung tissue by oligonucleotide array analysis.

2007-09-14 | E-GEOD-1888 | biostudies-arrayexpress

E-GEOD-1888

Project description:Transcription profiling of lung tissue of male Sprague Dawley rats after exposure to saline, isopropyl alcohol and sulfur mustard for 30 min, 1 hr, 3 hr, 6 hr, or 24 hr

2014-12-19 | E-GEOD-1888 | ExpressionAtlas

Effects of in utero and lactational exposure to new generation green plasticizers on adult male rats: a comparative study with di(2-ethylhexyl) phthalate

Project description:Di(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer, is a ubiquitous environmental pollutant and may act as an endocrine disruptor. Early life exposures to DEHP may result in anti-androgenic effects, impairing the development of the male reproductive tract. However, data on the long-lasting consequences of such DEHP exposures on adult male reproductive function are still rare and discrepant. Previously, we identified two novel plasticizers, 1,4 butanediol dibenzoate (BDB) and dioctyl succinate (DOS), as potential substitutes for DEHP that did not reproduce classically described endocrine disrupting phenotypes in prepubertal male offspring after maternal exposure. Here, we investigated the consequences of in utero and lactational exposure to BDB and DOS on adult male rat reproductive function in a comparative study with DEHP and a commercially available alternative plasticizer, 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH). Timed pregnant Sprague-Dawley rats were gavaged with vehicle or a test chemical (30 or 300 mg/kg/day) from gestation day 8 to postnatal day 21. While DEHP exposure (300 mg/kg/day) significantly increased epididymal weight in the adult, exposure to DINCH, BDB or DOS did not affect reproductive organ weights, steroid levels or sperm quality. Using a toxicogenomic microarray approach, we found that adult testicular gene expression was affected by exposure to the higher dose of DEHP; transcripts such as Nr5a2, Ltf or Runx2 were significantly downregulated, suggesting that DEHP was targeting estrogen signaling. Lesser effects were observed after treatment with either DINCH or BDB. DOS exposure did not produce such effects, confirming its potential as a responsible substitute for DEHP. The data deposited correspond to testicular gene expression in 90 day-old Sprague-Dawley rats after exposure to CORN OIL and 30 or 300 mg/kg/day DEHP, DINCH, BDB or DOS from gestational day 8 to post-natal day 21

2018-02-14 | GSE110553 | GEO

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