Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sebastian Pott
PROVIDER: E-GEOD-35910 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Genes & development 20120319 7
The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into the functions of Ebf1 at distinct stages of differentiation, we conditionally inactivated Ebf1. We found that Ebf1 is required for the proliferation, survival, and signaling of pro-B cells and peripheral B-cell subsets, including B1 cells and marginal zone B cells. The proliferation defect of Ebf1-deficient pro-B cells and the impaired expression of multiple cell cycle regulators are overcome ...[more]