Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Friedrich Bernhard Laub
PROVIDER: E-GEOD-3595 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kajimura Daisuke D Dragomir Cecilia C Ramirez Francesco F Laub Friedrich F
Gene 20061010 1-2
Gene targeting in mice has recently demonstrated that transcription factor KLF7 plays a critical role in neurite outgrowth and neuronal survival. Here we extended this genetic evidence by establishing the transcriptional profile of differentiating olfactory sensory neurons (OSNs) in Klf7(-/-) mice, and by identifying relevant genes that are directly regulated by KLF7. Functional clustering of DNA microarray data revealed that loss of KLF7 affects primarily the activity of genes involved in OSN d ...[more]