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Identification of Xenotropic MuLV-related virus

ABSTRACT: This series includes 20 microarrays used to identify Xenotropic MuLV-related virus (XMRV) in a set of human prostate tumors associated with R462Q RNASEL variant (Urisman, et al. 2006). The series includes 19 prostate tumor samples (VP) and a cell line control (HeLa).

ORGANISM(S): Viruses

SUBMITTER: Joseph DeRisi

PROVIDER: E-GEOD-3607 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.

Urisman Anatoly A Molinaro Ross J RJ Fischer Nicole N Plummer Sarah J SJ Casey Graham G Klein Eric A EA Malathi Krishnamurthy K Magi-Galluzzi Cristina C Tubbs Raymond R RR Ganem Don D Silverman Robert H RH DeRisi Joseph L JL

PLoS pathogens 20060331 3

Ribonuclease L (RNase L) is an important effector of the innate antiviral response. Mutations or variants that impair function of RNase L, particularly R462Q, have been proposed as susceptibility factors for prostate cancer. Given the role of this gene in viral defense, we sought to explore the possibility that a viral infection might contribute to prostate cancer in individuals harboring the R462Q variant. A viral detection DNA microarray composed of oligonucleotides corresponding to the most c ...[more]

PMID: 16609730

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