Transcriptomics Analysis of Lungs and Peripheral Blood of Crystalline Silica Exposed Rats

ABSTRACT: Non-invasive or minimally invasive surrogate approaches to detect/predict target organ toxicity have significant practical applications in occupational toxicology. Presently, using a rat model, we have investigated the potential application of peripheral blood transcriptomics as a practical approach to study the mechanisms of silica-induced pulmonary toxicity. Rats were exposed by inhalation to crystalline silica for one week (15 mg/m3, 6-hours/day, 5 days/week). Pulmonary toxicity and global gene expression profiles of lungs and peripheral blood were determined in the control and silica exposed rats at 32-weeks following termination of silica exposure. A significant elevation in bronchoalveolar lavage fluid (BALF) lactate dehydrogenase (LDH) activity and moderate histological changes in t

ORGANISM(S): Rattus norvegicus

SUBMITTER: Rajendran Sellamuthu 

PROVIDER: E-GEOD-36208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress