Unknown,Transcriptomics,Genomics,Proteomics

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PAR-CLIP of RBM4 and HIF-2a


ABSTRACT: To identify which mRNAs bind to RBM4/HIF-2a Two PAR-CLIPs were performed: One of an RBM4 immunoprecipitation, and the other of a HIF-2a immunoprecipitation and excising the associated RBM4 band.

ORGANISM(S): Homo sapiens

SUBMITTER: Jim Uniacke 

PROVIDER: E-GEOD-36247 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Protein synthesis involves the translation of ribonucleic acid information into proteins, the building blocks of life. The initial step of protein synthesis is the binding of the eukaryotic translation initiation factor 4E (eIF4E) to the 7-methylguanosine (m(7)-GpppG) 5' cap of messenger RNAs. Low oxygen tension (hypoxia) represses cap-mediated translation by sequestering eIF4E through mammalian target of rapamycin (mTOR)-dependent mechanisms. Although the internal ribosome entry site is an alte  ...[more]

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