Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hung-Cheng Lai
PROVIDER: E-GEOD-36259 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Molecular cancer therapeutics 20120510 8
A recent hypothesis for cancer chemoresistance posits that cytotoxic survival of a subpopulation of tumor progenitors drives the propagation of recurrent disease, underscoring the need for new therapeutics that target such primitive cells. To discover such novel compounds active against drug-resistant ovarian cancer, we identified a subset of chemoresistant ovarian tumor cells fulfilling current definitions of cancer-initiating cells from cell lines and patient tumors using multiple stemness phe ...[more]