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Transcription profiling of livers of C57BL/6 mice and LDL receptor deficient mice fed on either low fat or high fat diet to study liver gene expression associated with diet.

ABSTRACT: Examination of gene expression profiles from liver of C57BL/6 mice and LDL receptor deficient mice fed on either a low fat diet or a high fat Western-style diet for 12 weeks. Three replicates of each condition analyzed. Keywords = LDL receptor deficiency, high fat diet, atherosclerosis, liver

ORGANISM(S): Mus musculus

SUBMITTER: Allan Brasier

PROVIDER: E-GEOD-363 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway.

Recinos Adrian A Carr Boyd K BK Bartos David B DB Boldogh Istvan I Carmical J Russ JR Belalcazar L Maria LM Brasier Allan R AR

Physiological genomics 20040706 1

Diet-induced changes in serum lipoproteins are a major risk factor for the development of atherosclerosis, the leading cause of mortality in Westernized countries. Atherosclerosis is now appreciated to be a systemic inflammatory disease where increased synthesis of inducible proteins by the liver, such as C-reactive protein (CRP) and others, may play roles in accelerating the disease process. To systematically investigate the genetic response of the liver to diet-induced atherosclerosis, we appl ...[more]

PMID: 15238619

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