Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: David Hot
PROVIDER: E-GEOD-36481 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Couturier-Maillard Aurélie A Secher Thomas T Rehman Ateequr A Normand Sylvain S De Arcangelis Adèle A Haesler Robert R Huot Ludovic L Grandjean Teddy T Bressenot Aude A Delanoye-Crespin Anne A Gaillot Olivier O Schreiber Stefan S Lemoine Yves Y Ryffel Bernhard B Hot David D Nùñez Gabriel G Chen Grace G Rosenstiel Philip P Chamaillard Mathias M
The Journal of clinical investigation 20130102 2
Instability in the composition of gut bacterial communities (dysbiosis) has been linked to common human intestinal disorders, such as Crohn's disease and colorectal cancer. Here, we show that dysbiosis caused by Nod2 deficiency gives rise to a reversible, communicable risk of colitis and colitis-associated carcinogenesis in mice. Loss of either Nod2 or RIP2 resulted in a proinflammatory microenvironment that enhanced epithelial dysplasia following chemically induced injury. The condition could b ...[more]