Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Shiuan Chen
PROVIDER: E-GEOD-36509 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kubo Makoto M Kanaya Noriko N Petrossian Karineh K Ye Jingjing J Warden Charles C Liu Zheng Z Nishimura Reiki R Osako Tomofumi T Okido Masayuki M Shimada Kazuo K Takahashi Masato M Chu Peiguo P Yuan Yate-Ching YC Chen Shiuan S
Breast cancer research and treatment 20121118 1
Aromatase inhibitors (AIs) are important drugs for treating postmenopausal patients with hormone receptor-positive breast cancer. However, acquired resistance to AI therapies is a significant problem. Our study has revealed that the histone deacetylase inhibitor LBH589 treatment abrogated growth of AI-resistant cells in vitro and in vivo, causing cell cycle G2/M arrest and induced apoptosis. LBH589 treatment also reduced the level of NF-κB1 which is overexpressed when AI resistance develops. Ana ...[more]