Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Siomycin A treatment in prostate cancer cell lines PC3 and LNCaP

ABSTRACT: Siomycin A treatment in prostate cancer cell lines resulted in a concurrent inhibition of specific cell cycle genes and strongly impaired cell viability. Illumina microarray experiments were done using PC3 and LNCaP cell lines treated with 0.5 microM Siomaycin A either 24h or 48h in triplicates.

ORGANISM(S): Homo sapiens

SUBMITTER: Ruprecht Kuner

PROVIDER: E-GEOD-36531 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.

Kuner Ruprecht R Fälth Maria M Pressinotti Nicole Chui NC Brase Jan C JC Puig Sabrina Balaguer SB Metzger Jennifer J Gade Stephan S Schäfer Georg G Bartsch Georg G Steiner Eberhard E Klocker Helmut H Sültmann Holger H

Journal of molecular medicine (Berlin, Germany) 20120904 2

Loss of cell cycle control is a prerequisite for cancer onset and progression. In prostate cancer, increased activity of cell cycle genes has been associated with prognostic parameters such as biochemical relapse and survival. The identification of novel oncogenic and druggable targets in patient subgroups with poor prognosis may help to develop targeted therapy approaches. We analyzed prostate cancer and corresponding benign tissues (n = 98) using microarrays. The comparison of high- and low-gr ...[more]

PMID: 22945237

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Dataset Information

Siomycin A treatment in prostate cancer cell lines PC3 and LNCaP

Publications

The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.

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