Ontology highlight
ABSTRACT:
ORGANISM(S): synthetic construct
SUBMITTER: Helio Pais
PROVIDER: E-GEOD-36540 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Sorefan Karim K Pais Helio H Hall Adam E AE Kozomara Ana A Griffiths-Jones Sam S Moulton Vincent V Dalmay Tamas T
Silence 20120530 1
<h4>Background</h4>The use of nucleic acid-modifying enzymes has driven the rapid advancement in molecular biology. Understanding their function is important for modifying or improving their activity. However, functional analysis usually relies upon low-throughput experiments. Here we present a method for functional analysis of nucleic acid-modifying enzymes using next generation sequencing.<h4>Findings</h4>We demonstrate that sequencing data of libraries generated by RNA ligases can reveal nove ...[more]