Polycomb Cbx orthologs mediate the balance between Hematopoietic Stem Cell self-renewal and differentiation
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ABSTRACT: By genome-wide ChIP-seq analyses we show that Cbx7 and Cbx8 share ~95% of their targets in bone marrow cells. Cbx7 and Cbx8 have only ~200 targets that are not overlapping between the two proteins. These distinct Cbx7 and Cbx8 targets show reciprocal expression patterns along hematopoietic differentiation. Overexpression of empty vector (negative control), flag-Cbx7 and flag-Cbx8 in 5-FU treated bone marrow cells (progenitor and stem cells), followed by 1 week culture and subsequent ChIP using flag-M2 agarose beads.
ORGANISM(S): Mus musculus
SUBMITTER: Leonid Bystrykh
PROVIDER: E-GEOD-36658 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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