Mutant p53 cooperates with ETS2 to promote etoposide resistance
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Luis Martinez
PROVIDER: E-GEOD-36752 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Mutant p53 cooperates with ETS2 to promote etoposide resistance.
Do Phi M PM Varanasi Lakshman L Fan Songqing S Li Chunyang C Kubacka Iwona I Newman Virginia V Chauhan Krishna K Daniels Silvano Rakeem SR Boccetta Maurizio M Garrett Michael R MR Li Runzhao R Martinez Luis A LA
Genes & development 20120401 8
Mutant p53 (mtp53) promotes chemotherapy resistance through multiple mechanisms, including disabling proapoptotic proteins and regulating gene expression. Comparison of genome wide analysis of mtp53 binding revealed that the ETS-binding site motif (EBS) is prevalent within predicted mtp53-binding sites. We demonstrate that mtp53 regulates gene expression through EBS in promoters and that ETS2 mediates the interaction with this motif. Importantly, we identified TDP2, a 5'-tyrosyl DNA phosphodiest ...[more]
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