Effects of TCDD on differentiating NHEKs
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Lawrence Kennedy
PROVIDER: E-GEOD-36796 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation.
Kennedy Lawrence H LH Sutter Carrie Hayes CH Leon Carrion Sandra S Tran Quynh T QT Bodreddigari Sridevi S Kensicki Elizabeth E Mohney Robert P RP Sutter Thomas R TR
Toxicological sciences : an official journal of the Society of Toxicology 20121114 1
Chloracne is commonly observed in humans exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); yet, the mechanism of toxicity is not well understood. Using normal human epidermal keratinocytes, we investigated the mechanism of TCDD-mediated enhancement of epidermal differentiation by integrating functional genomic, metabolomic, and biochemical analyses. TCDD increased the expression of 40% of the genes of the epidermal differentiation complex found on chromosome 1q21 and 75% of the genes requir ...[more]
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