A unifying model for mTORC1-mediated regulation of mRNA translation
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Carson Thoreen
PROVIDER: E-GEOD-36892 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A unifying model for mTORC1-mediated regulation of mRNA translation.
Thoreen Carson C CC Chantranupong Lynne L Keys Heather R HR Wang Tim T Gray Nathanael S NS Sabatini David M DM
Nature 20120502 7396
The mTOR complex 1 (mTORC1) kinase nucleates a pathway that promotes cell growth and proliferation and is the target of rapamycin, a drug with many clinical uses. mTORC1 regulates messenger RNA translation, but the overall translational program is poorly defined and no unifying model exists to explain how mTORC1 differentially controls the translation of specific mRNAs. Here we use high-resolution transcriptome-scale ribosome profiling to monitor translation in mouse cells acutely treated with t ...[more]
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