Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jian Xu
PROVIDER: E-GEOD-36994 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Xu Jian J Shao Zhen Z Glass Kimberly K Bauer Daniel E DE Pinello Luca L Van Handel Ben B Hou Serena S Stamatoyannopoulos John A JA Mikkola Hanna K A HK Yuan Guo-Cheng GC Orkin Stuart H SH
Developmental cell 20121004 4
Gene-distal enhancers are critical for tissue-specific gene expression, but their genomic determinants within a specific lineage at different stages of development are unknown. Here we profile chromatin state maps, transcription factor occupancy, and gene expression profiles during human erythroid development at fetal and adult stages. Comparative analyses of human erythropoiesis identify developmental stage-specific enhancers as primary determinants of stage-specific gene expression programs. W ...[more]