Unknown,Transcriptomics,Genomics,Proteomics

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HF liver: Control vs. Plin2-ASO treated


ABSTRACT: Transcriptional profiling of mouse liver comparing control, scrambled-oligonucleotides (Cont)-treated mice with Perilipin 2-antisense oligonucleotides (Plin2-ASO)-treated mice. C57BL/6 mice on a high-fat diet were treated with oligonucleotides in vivo. The goal was to determine the effects of Plin2 down-regulation in the liver on global gene expression. Two-condition experiment, control oligonucleotides vs. Plin2-antisense oligonucleotides. Biological replicates: 4 control replicates, 4 Plin2-ASO replicates.

ORGANISM(S): Mus musculus

SUBMITTER: yumi imai 

PROVIDER: E-GEOD-37011 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression.

Imai Yumi Y   Boyle Siobhan S   Varela Gladys M GM   Caron Emilie E   Yin Xiaoyan X   Dhir Raina R   Dhir Ravindra R   Graham Mark J MJ   Ahima Rexford S RS  

Physiological genomics 20120925 22


Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. We previously showed that Perilipin 2 (Plin2), a member of lipid droplet protein family, is markedly increased in fatty liver, and its reduction in the liver of diet-induced obese mice by antisense oligonucleotide (ASO) decreased steatosis and enhanced insulin sensitivity. Plin2-ASO treatment markedly suppressed lipogenic gene expression. To gain a better understanding of the biological role of Plin2 in liver, w  ...[more]

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