Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Diu Nguyen
PROVIDER: E-GEOD-37061 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bousquet Marina M Nguyen Diu D Chen Cynthia C Shields Lauren L Lodish Harvey F HF
Haematologica 20120611 11
<h4>Background</h4>We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce leukemia. In this study, we investigated the mechanism of myeloid transformation by miR-125b.<h4>Design and methods</h4>To investigate the consequences of miR-125b over-expr ...[more]