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Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart1]

ABSTRACT: Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence three-condition experiment: blastocyst (B), embryo of poor quality (E) AND immature oocytes (VG).

ORGANISM(S): Homo sapiens

SUBMITTER: Raluca TEUSAN

PROVIDER: E-GEOD-37110 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic assessment of human cumulus cell marker genes as predictors of oocyte developmental competence: impact of various experimental factors.

Feuerstein Prisca P Puard Vincent V Chevalier Catherine C Teusan Raluca R Cadoret Veronique V Guerif Fabrice F Houlgatte Remi R Royere Dominique D

PloS one 20120727 7

<h4>Background</h4>Single embryo transfer (SET) is the most successful way to reduce the frequency of multiple pregnancies following in vitro fertilisation. However, selecting the embryo for SET with the highest chances of pregnancy remains a difficult challenge since morphological and kinetics criteria provide poor prediction of both developmental and implantation ability. Partly through the expression of specific genes, the oocyte-cumulus interaction helps the oocyte to acquire its development ...[more]

PMID: 22848380

Similar Datasets

Differentiating factors of cumulus cells related to quality of the human oocyte

Project description:Single embryo transfer (SET) is the most successful way to reduce the frequency of multiple pregnancies during in vitro fertilisation. However, selecting the embryo with the highest chances of pregnancy for SET remains a difficult challenge, since morphological and kinetics criteria provide poor prediction of both developmental and implantation ability. Partly through the expression of specific genes, the oocyte-cumulus interaction helps the oocyte to acquire its developmental competence. Our aim was therefore to identify at the level of cumulus cells (CCs) any genes related to oocyte developmental competence. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series.

2012-12-10 | E-GEOD-37277 | biostudies-arrayexpress

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart3]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence 2-condition experiment: blastocyst (B) AND embryo of poor quality (E).

2012-12-10 | E-GEOD-37116 | biostudies-arrayexpress

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart2]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence 2-condition experiment: blastocyst (B) ans embryo of poor quality (E).

2012-12-10 | E-GEOD-37117 | biostudies-arrayexpress

Differentiating factors of cumulus cells related to quality of the human oocyte

2012-12-10 | GSE37277 | GEO

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart2]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence

2012-12-10 | GSE37117 | GEO

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart3]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence

2012-12-10 | GSE37116 | GEO

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart1]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence

2012-12-10 | GSE37110 | GEO

Assessing transcriptomes of mouse cumulus cells, mural granulosa cells, and cumulus-oocyte complexes

Project description:Transcriptomes of mouse mural granulosa cells were sequenced to identify transcripts expressed in mural granulosa cells of ovaries. Moreover, transcriptomes of cumulus cells were compared between those of young (2 month-old) and old mice (10 month-old) to assess the effects of ageing on cumulus cells. In addition, transcriptomes of cumulus-oocyte complexes were compared between DBA/2 and (C57BL/6 x DBA/2)F1 mice to assess the strain differences.

2016-04-15 | GSE80326 | GEO

Palmitoylated proteins in bovine ovarian cumulus-oocyte complexes

Project description:The palmitoyl-proteome of bovine cumulus-oocyte complexes (COCs) cells was investigated by combining acyl-biotin exchange chemistry and quantitative mass spectrometry analysis.

2022-02-15 | PXD020540 | Pride

The bovine cumulus proteome of cumulus oocyte complexes that successfully matured or failed to mature after maturation in-vitro and in-vivo

Project description:The oocyte forms a complex with their somatic cumulus cells within the follicle throughout the preovulatory maturation steps. Cumulus cells support their oocyte not only through mechanical protection but also with a close bidirectional exchange of metabolites. Analysis of the oocytes cumulus gives the opportunity to explore non-invasively oocytal well-being and quality. In vitro maturation (IVM) is the first rate-limiting step in in vitro embryo production. Analysis of protein expression in cumulus cells around this critical step helps to explore the impact of maturation conditions and to examine an influence on maturational competence of the oocyte. The goal of this study was the comparison of the cumulus proteome of oocytes with and without maturational competence matured under in vivo and in vitro conditions. Therefore twenty cumulus samples corresponding to single oocytes were analysed. Half of the samples were matured in vivo and the other half in vitro. For each maturation group, cumulus from oocytes matured successfully (SM; n=5) and failed to mature (FM; n=5) were analysed.

2020-06-30 | PXD016679 | Pride

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