Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hyeshik Chang
PROVIDER: E-GEOD-37112 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cho Jun J Chang Hyeshik H Kwon S Chul SC Kim Baekgyu B Kim Yoosik Y Choe Junho J Ha Minju M Kim Yoon Ki YK Kim V Narry VN
Cell 20121025 4
LIN28 plays a critical role in developmental transition, glucose metabolism, and tumorigenesis. At the molecular level, LIN28 is known to repress maturation of let-7 microRNAs and enhance translation of certain mRNAs. In this study, we obtain a genome-wide view of the molecular function of LIN28A in mouse embryonic stem cells by carrying out RNA crosslinking-immunoprecipitation-sequencing (CLIP-seq) and ribosome footprinting. We find that, in addition to let-7 precursors, LIN28A binds to a large ...[more]