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DPN and Tamoxifen treatments of parathyroid adenoma cells

ABSTRACT: Stimulation of estrogen receptor beta in PHPT, genetic changes after 24 and 48h of treatments vs. Control Treatment of parathyroid adenomas (4 patients, 4 adenomas) with DPN 24h (4 samples), DPN 48h (4 samples), OHT 24h (4 samples), OHT 48h (4 samples), control 24h (3 samples), control 48h (4 samples). Omission of 1 sample based on low RNA quality.

ORGANISM(S): Homo sapiens

SUBMITTER: Mikael Huss

PROVIDER: E-GEOD-37211 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Evidence of a functional estrogen receptor in parathyroid adenomas.

Haglund Felix F Ma Ran R Huss Mikael M Sulaiman Luqman L Lu Ming M Nilsson Inga-Lena IL Höög Anders A Juhlin C Christofer CC Hartman Johan J Larsson Catharina C

The Journal of clinical endocrinology and metabolism 20120928 12

<h4>Context</h4>Primary hyperparathyroidism (PHPT) is most frequently present in postmenopausal women. Although the involvement of estrogen has been suggested, current literature indicates that parathyroid tumors are estrogen receptor (ER) α negative.<h4>Objective</h4>The aim of the study was to evaluate the expression of ERs and their putative function in parathyroid tumors.<h4>Design</h4>A panel of 37 parathyroid tumors was analyzed for expression and promoter methylation of the ESR1 and ESR2 ...[more]

PMID: 23024189

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