Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Dimos Gaidatzis
PROVIDER: E-GEOD-37226 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Towbin Benjamin D BD González-Aguilera Cristina C Sack Ragna R Gaidatzis Dimos D Kalck Véronique V Meister Peter P Askjaer Peter P Gasser Susan M SM
Cell 20120801 5
The factors that sequester transcriptionally repressed heterochromatin at the nuclear periphery are currently unknown. In a genome-wide RNAi screen, we found that depletion of S-adenosylmethionine (SAM) synthetase reduces histone methylation globally and causes derepression and release of heterochromatin from the nuclear periphery in Caenorhabditis elegans embryos. Analysis of histone methyltransferases (HMTs) showed that elimination of two HMTs, MET-2 and SET-25, mimics the loss of SAM syntheta ...[more]