Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andreas Gruber
PROVIDER: E-GEOD-37398 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Martin Georges G Gruber Andreas R AR Keller Walter W Zavolan Mihaela M
Cell reports 20120607 6
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3' untranslated regions, the latter typically associated with higher transcript stability and increased protein production. To understand the dynamics of polyadenylation site usage, we performed transcriptome-wide mapping of both binding sites of 3' end processing factors CPSF-160, CPSF-100, CPSF-73, CPSF-30, Fip1, CstF-64, CstF-64τ, CF I(m)25, CF I(m)59, and CF I(m)68 and 3' end processing sites in HEK293 cells. We found ...[more]