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Expression data from siRNAs against SLC45A3-ELK4 in LNCaP cells.

ABSTRACT: SLC45A3-ELK4 is found in LNCaP and other prostate cancer samples. We used microarrays to detail the global changes of gene expression when LNCaP cells were treated with siRNAs against SLC45A3-ELK4. We transfected LNCaP cells with siRNAs against SLC45A3-ELK4 and siGl2 control. 72hrs later, RNAs were harvested.

ORGANISM(S): Homo sapiens

SUBMITTER: Hui Li

PROVIDER: E-GEOD-37410 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation.

Zhang Yanmei Y Gong Mei M Yuan Huiling H Park Hong G HG Frierson Henry F HF Li Hui H

Cancer discovery 20120619 7

<h4>Unlabelled</h4>Gene fusion is a common event in cancer. The fusion RNA and protein products often play causal roles in tumorigenesis and therefore represent ideal diagnostic and therapeutic targets. Formerly, fusion chimeric products in cancer were thought to be produced solely by chromosomal translocation. Here, we show that a chimeric SLC45A3-ELK4 RNA is generated in the absence of chromosomal rearrangement. We showed that it is not a product of RNA trans-splicing, but formed by cis-splici ...[more]

PMID: 22719019

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Expression data from siRNAs against SLC45A3-ELK4 in LNCaP cells.

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