Dataset Information
Transcription profiling of 47 human breast tumor cases
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): sporadic basal-like breast cancer
SUBMITTER: Andrea Richardson
PROVIDER: E-GEOD-3744 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
X chromosomal abnormalities in basal-like human breast cancer.
Cancer cell 20060201 2
Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosom ...[more]
