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Transcription profiling of 47 human breast tumor cases

ABSTRACT: Gene expression for 47 human breast tumor cases (normalized by GCRMA for global expression analysis)

ORGANISM(S): Homo sapiens

DISEASE(S): sporadic basal-like breast cancer

SUBMITTER: Andrea Richardson

PROVIDER: E-GEOD-3744 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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X chromosomal abnormalities in basal-like human breast cancer.

Richardson Andrea L AL Wang Zhigang C ZC De Nicolo Arcangela A Lu Xin X Brown Myles M Miron Alexander A Liao Xiaodong X Iglehart J Dirk JD Livingston David M DM Ganesan Shridar S

Cancer cell 20060201 2

Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosom ...[more]

PMID: 16473279

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