Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hung-I Chen
PROVIDER: E-GEOD-37679 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Panneerdoss Subbarayalu S Chang Yao-Fu YF Buddavarapu Kalyan C KC Chen Hung-I Harry HI Shetty Gunapala G Wang Huizhen H Chen Yidong Y Kumar T Rajendra TR Rao Manjeet K MK
PloS one 20120720 7
Although decades of research have established that androgen is essential for spermatogenesis, androgen's mechanism of action remains elusive. This is in part because only a few androgen-responsive genes have been definitively identified in the testis. Here, we propose that microRNAs--small, non-coding RNAs--are one class of androgen-regulated trans-acting factors in the testis. Specifically, by using androgen suppression and androgen replacement in mice, we show that androgen regulates the expre ...[more]