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Mammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Tim Roloff

PROVIDER: E-GEOD-37714 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.

Loedige Inga I Gaidatzis Dimos D Sack Ragna R Meister Gunter G Filipowicz Witold W

Nucleic acids research 20121103 1

TRIM-NHL proteins are conserved regulators of development and differentiation but their molecular function has remained largely elusive. Here, we report an as yet unrecognized activity for the mammalian TRIM-NHL protein TRIM71 as a repressor of mRNAs. We show that TRIM71 is associated with mRNAs and that it promotes translational repression and mRNA decay. We have identified Rbl1 and Rbl2, two transcription factors whose down-regulation is important for stem cell function, as TRIM71 targets in m ...[more]

PMID: 23125361

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