Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression of mouse embryonic gonad

ABSTRACT: To elucidate the function of NANOS2 to regulate the transcriptome in embryonic male germ cells, we performed expression microarray analysis of the embyornic gonads of the Nanos2+/-, Nanos2-/- male and wild type female from E12.5 to E15.5. The Nanos2+/- and Nanos2-/- female gonads at E15.5 were analyzed as a negative control. Biological duplicates were examined at each stage, genotype, and sex for each experiment.

ORGANISM(S): Mus musculus

SUBMITTER: Rie Saba 

PROVIDER: E-GEOD-37716 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells.

Wu Quan Q   Kanata Kohei K   Saba Rie R   Deng Chu-Xia CX   Hamada Hiroshi H   Saga Yumiko Y  

Development (Cambridge, England) 20121205 2

Testicular development in the mouse is triggered in somatic cells by the function of Sry followed by the activation of fibroblast growth factor 9 (FGF9), which regulates testicular differentiation in both somatic and germ cells. However, the mechanism is unknown. We show here that the nodal/activin signaling pathway is activated in both male germ cells and somatic cells. Disruption of nodal/activin signaling drives male germ cells into meiosis and causes ectopic initiation of female-specific gen  ...[more]

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