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Role of Nanos2 in the embryonic male gonad

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Rie Saba

PROVIDER: E-GEOD-37720 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells.

Wu Quan Q Kanata Kohei K Saba Rie R Deng Chu-Xia CX Hamada Hiroshi H Saga Yumiko Y

Development (Cambridge, England) 20121205 2

Testicular development in the mouse is triggered in somatic cells by the function of Sry followed by the activation of fibroblast growth factor 9 (FGF9), which regulates testicular differentiation in both somatic and germ cells. However, the mechanism is unknown. We show here that the nodal/activin signaling pathway is activated in both male germ cells and somatic cells. Disruption of nodal/activin signaling drives male germ cells into meiosis and causes ectopic initiation of female-specific gen ...[more]

PMID: 23221368

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