Expression response of Brucella melitensis strain 16M (ATCC23456) to erythritol
Ontology highlight
ABSTRACT:
ORGANISM(S): Brucella melitensis bv. 1 str. 16M
SUBMITTER: Erik Petersen
PROVIDER: E-GEOD-37819 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:The transcriptional regulator MucR was identified as highly attenuated in a mutagenesis screen conducted by this laboratory. MucR has been described as a key regulator of exopolysaccharide synthesis in closely related Rhizobials soil symbionts. The goal of this study was to apply custom Brucella melitensis oligonucleotide microarrays to identify the regulatory targets of MucR. These studies revealed that MucR's regulation of exopolysaccharide synthesis is also conserved in Brucella melitensis and is also a key regulator of iron sequestering/storage and denitrification. Keywords: Microarray comparison of a genetically modified organism compared to wild type. There are 3 biological replicates isolated from Brucella melitensis wild type 16M and from 16M∆mucR.
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