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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of major depression peripheral blood mononuclear cells (PBMCs) at clinical remission compared to severe acute state

ABSTRACT: PBMCs from major depressive episode (MDE) subjects were obtained at two time points: during a severe episode of depression and eight week later after clinical remission. PBMCs from sex- and age-machted controls were also obtained at an eight weeks interval. PBMC total RNAs from MDE and control subjects were profiled after hybridization with Agilent SurePrint G3 Human GE 8x60K Microarray to identify blood biomarkers of MDE. Total RNAs were extracted from 36 samples including: 9 control and 9 MDE subjects at two point of time (first and eight week later)

ORGANISM(S): Homo sapiens

SUBMITTER: El ChÃ©rif Ibrahim

PROVIDER: E-GEOD-38206 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode.

Belzeaux R R Bergon A A Jeanjean V V Loriod B B Formisano-Tréziny C C Verrier L L Loundou A A Baumstarck-Barrau K K Boyer L L Gall V V Gabert J J Nguyen C C Azorin J-M JM Naudin J J Ibrahim E C EC

Translational psychiatry 20121113

To date, it remains impossible to guarantee that short-term treatment given to a patient suffering from a major depressive episode (MDE) will improve long-term efficacy. Objective biological measurements and biomarkers that could help in predicting the clinical evolution of MDE are still warranted. To better understand the reason nearly half of MDE patients respond poorly to current antidepressive treatments, we examined the gene expression profile of peripheral blood samples collected from 16 s ...[more]

PMID: 23149449

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Transcription profiling of major depression peripheral blood mononuclear cells (PBMCs) at clinical remission compared to severe acute state

Project description:PBMCs from major depressive episode (MDE) subjects were obtained at two time points: during a severe episode of depression and eight week later after clinical remission. PBMCs from sex- and age-machted controls were also obtained at an eight weeks interval. PBMC total RNAs from MDE and control subjects were profiled after hybridization with Agilent SurePrint G3 Human GE 8x60K Microarray to identify blood biomarkers of MDE.

2012-12-20 | GSE38206 | GEO

Expression data from peripheral blood lymphocytes of major depression, subsyndromal symptomatic depression, and healthy controls

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2012-03-21 | E-GEOD-32280 | biostudies-arrayexpress

Limited systemic sclerosis patients with PAH show biomarkers of inflammation and vascular injury

Project description:Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury Forty-nine PBMC samples were obtained from 21 lSSc subjects without PAH (lSSc-noPAH), 15 lSSc subjects with PAH (lSSc-PAH), and 10 healthy controls; three subjects provided PBMCs one year later. Genome-wide gene expression was measured for each sample. Gene expression clearly distinguished lSSc samples from healthy controls, and separated lSSc-PAH from lSSc-NoPAH patients. The gene expression and cytokine profiles of lSSc-PAH patients suggest the presence of activated monocytes, and show markers of vascular injury and inflammation. Sample vs reference, total RNA isolated from peripheral blood mononuclear cells (PBMC), 21 lSSc subjects without PAH (lSSc-noPAH), 15 lSSc subjects with PAH (lSSc-PAH), and 10 healthy controls

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Gene expressions data of Multiple Sclerosis stages, Clinical Isolated Syndrome and healthy controls

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Limited systemic sclerosis patients with PAH show biomarkers of inflammation and vascular injury

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The effect of simulated night shift work on the circadian regulation of the human transcriptome

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2018-05-08 | GSE107537 | GEO

Transcription profiling of human endomyocardial biopsies before, during and after cardiac allograft rejection

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2007-12-12 | E-GEOD-4315 | biostudies-arrayexpress

Gene expression profile of PBMCs in response to metreleptin treatment at different time points.

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2013-03-04 | E-GEOD-36990 | biostudies-arrayexpress

Systems Signature Reveals Unique Remission-path of Diabetes Generated by Gastric Bypass Surgery

Project description:Gastric bypass surgery (GBP) emerging as a powerful tool for treatment of obesity has been applied for remission of diabetes. However, the GBP global molecular effects on diabetes remission independent of weight loss remain largely unknown. We profiled plasma metabolites and proteins of 10 normoglycemic obese (NO) and 9 diabetic obese (DO) patients at 1-week, 3-months and 1-year stages after Roux-en-Y gastric bypass (RYGB) as well pre-RYGB stage, by which 146 proteins and 128 metabolites were detected from both NO and DO groups at all four stages. By analyzing a set of bi-molecular associations among the corresponding network of the subjects with our newly developed computational method, we defined the representing physiological states (called the edge-states, in contrast to the traditional node-states) and the related molecular networks of NO and DO patients, respectively. The PCA results and hubnetworks of NO subjects were significantly different from those of DO patients; particularly, the hub-network rearrangement of both groups differentially went through after RYGB. In conclusion, by developing network-based systems signatures rather than relying on individual molecules, we for the first time reveal that RYGB generates a unique recovering-path for diabetes remission independent of weight loss.

2017-12-13 | PXD008071 | Pride

Epigenetic patterns with aging and exercise are associated with indicators of healthspan in humans

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